VOXZOGO ® (vosoritide for injection) is the only medicine indicated to increase linear growth in children with achondroplasia (4 months of age and older) whose epiphyses are not closed 1. The ...

Researchers uncover a redox-regulated mechanism that determines whether bone fractures heal or progress to non-union. Bone has an extraordinary capacity to heal after injury, restoring its structure ...

Bone fractures usually heal efficiently, but in some patients this process fails, causing nonunion. A recent study identifies Apex1 as a redox-regulated driver of fracture repair. Using genetic mouse ...

Bone has an extraordinary capacity to heal after injury, restoring its structure and mechanical function without leaving a scar. Yet for a clinically significant number of patients, this regenerative ...

Correspondence to Dr Hui Liu, Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University; Guangdong Province Key Laboratory of Orthopaedics and Traumatology, Guangzhou 510080, ...

We’ve long blamed osteoarthritis on “wear and tear,” the price of a life well-lived. But could the cause be a more ancient culprit: a misfired developmental program that once built our skeletons and ...

In a recent interview with Bitcoin Magazine, Shinobi sat down with Andrew Poelstra from Blockstream to discuss his colleague Rusty Russell’s ambitious proposal. Rusty plans to restore several ...

eTRS National Resource Centre for Rare Disorders, Oslo, Norway Achondroplasia is the most common form of dwarfism in humans, caused by a common pathogenic variant in the gene encoding fibroblast ...

In a phase 2 clinical trial, the safety and efficacy of vosoritide was similar in children aged younger than 5 years to those older than 5 years. The FDA has approved an expanded use of vosoritide ...

Our editorial process produces two outputs: (i) public reviews designed to be posted alongside the preprint for the benefit of readers; (ii) feedback on the manuscript for the authors, including ...