The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Ferulic acid suppresses ileal smooth muscle contraction by inhibiting calcium ion influx through voltage-dependent calcium channels. This action may help prevent or treat excessive intestinal motility ...

Calcium is the most abundant mineral in the body, playing a vital role in numerous physiological functions. From forming and maintaining strong bones and teeth to facilitating muscle movement and ...

A research team at Toho University has revealed that ferulic acid (FA), a polyphenol abundant in rice bran, suppresses intestinal smooth muscle contractions by inhibiting voltage-dependent calcium ...

Calreticulin is a protein with many roles, including calcium regulation and helping other proteins fold. How did scientists discover calreticulin and its functions? In their most basic state, proteins ...

Muscle contraction is the tightening, shortening, or lengthening of muscles when you do some activity. It can happen when you hold or pick up something, or when you stretch or exercise with weights.

The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...