After nearly four decades of research, Mayo Clinic scientists have revealed the molecular structure of protein kinase C beta ...

Phosphorylation of histone H3 threonine 3 (H3T3) by Haspin recruits the chromosomal passenger complex to the inner centromere and ensures proper cell cycle progression through mitosis. The mechanism ...

mTOR is an evolutionarily conserved serine/threonine kinase with a crucial role in regulating protein synthesis, cell growth, survival, and metabolism [1, 2]. Extensive studies have established that ...

Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the tree of life—from algae to helminths to mammals. Now, scientists have ...

A Parkinsonian mystery—how PINK1 locks onto malfunctioning mitochondria—now has a structural solution. Researchers at the University of Melbourne led by Sylvie Callegari, Alisa Glukhova, and David ...