Intestinal epithelial cells (IECs) not only have an absorption function but also act as a physical barrier between the body and the intestinal bacterial flora. Damage to IECs leads to the breakdown of ...

While in vivo animal models are commonly employed for pharmacokinetic studies, they are often expensive, low in throughpu,t and typically fail to accurately replicate key characteristics of the human ...

In vivo, the intestinal epithelium interacts with the neighboring environment through complex crosstalk, which involves components such as the immune system, tissue microenvironment, and gut microbes.

The gastrointestinal (GI) epithelium is the body’s first line of defense to luminal contents such as food, microbiota, pharmaceuticals, and toxins. A small pool of proliferative stem and progenitor ...

A recent study published in Nature Genetics investigated the genetic factors that enable Shigella flexneri to colonize the human gut. The researchers focused on identifying specific genes required for ...

Intestinal tuft cells divide to make new cells when immunological cues trigger them. Additionally, in contrast to progenitor- and stem cells, tuft cells can survive severe injury such as irradiation ...

A recent study in Nature Microbiology investigated how Salmonella typhimurium targets the gut epithelium and localizes to the follicle-associated epithelium (FAE) of the small intestine. The human gut ...