Infiltration of the tumor microenvironment (TME) with cytotoxic T cells (CTLs) which recognize tumor-associated antigens (TAAs and TSAs) is required for the clinical efficacy of immunotherapy and for ...

Laguna Biotherapeutics, Inc. (Laguna), a clinical-stage biotechnology company focused on novel live bacterial therapeutics, ...

Recently, a research team led by Professor Zhengping Xu of Zhejiang University School of Medicine and its affiliated Sir Run Run Shaw Hospital published a paper in Science Bulletin titled ...

The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...

Diabetes mellitus affects more than 500 million people worldwide, and both Type 1 (T1D) and Type 2 (T2D) forms converge on a common endpoint: the loss or ...

Around 8% of the human genome is made up of ancient viral sequences—endogenous retroviruses (ERVs) that integrated into our ancestors’ germline millions of years ago. Once thought to be inert genetic ...

Plant cells do not easily abandon their mature identity. In apple, that transformation is especially important because somatic embryogenesis underpins regeneration and genetic improvement.

In recent years, we have come to appreciate that loss or dysfunction of insulin-producing islet beta cells underlies virtually all major forms of diabetes mellitus. In type 1 diabetes, beta cells ...