Cellular senescence is a state where cells permanently stop dividing but remain metabolically active, often in response to stress or damage. Senescent cells are known to play a key role in wound ...

Senescent cells walk a tightrope, risking cell death with high levels of iron and other damaging agents, but compensating for this by overproducing a protective protein, GPX4, which staves off death.

Cellular senescence is a state characterized by permanent cell-cycle arrest, increased expression of markers such as p16^INK4a and p21^CIP1/WAF1, elevated DNA damage signals (e.g., γ-H2AX) and a ...

Chemotherapy kills cancer cells, but it also leaves behind something troubling: damaged cells that stop dividing yet refuse ...

A new set of drugs exploit a recently-revealed weakness in 'zombie-like' – or senescent – cells that could lead to new ...

Most of us think about aging as something that happens to us gradually, almost invisibly, like the slow fading of a ...

T cell senescence occurs in the TME, affecting cancer prognosis and immunotherapy efficacy. The TME induces T cell senescence through multiple pathways, including persistent stimulation by ...

Triple-negative breast cancer (TNBC), particularly the luminal androgen receptor (LAR) subtype, presents significant ...

Researchers built an immune-aging clock from 1.2 million cells, revealing T cells as key indicators of immune aging. They ...

T cell senescence occurs in the TME, affecting cancer prognosis and immunotherapy efficacy. The TME induces T cell senescence through multiple pathways, including persistent stimulation by ...